The Pharmacological Frontier: Mapping Receptor Affinity and Metabolic Fingerprints
1. High-Affinity Binding: The Ki Constant In 2026, researchers define potency through the Inhibition Constant (Ki). This value measures the concentration needed to bind 50% of available receptors. A lower value signifies a tighter molecular grip on the CB1 receptor. These high-affinity ligands produce sustained receptor activation. This activation far exceeds the “ceiling effect” of …
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